Thymidine
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Thymidine

Product No.:SB058
CAS No.:50-89-5
Synonyms:dT;2-dT;Deoxythymidine;Doxribtimine
Formular:C10H14N2O5
Molecular weight:242.23
Production capacity:The annual output reaches the scale of 1,000 tons.
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Description

Technical Parameters

Thymidine

Synonyms:1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;Thymidine For Biochemistry;

2'-Deoxythymidine;2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-beta-D-ribofuranosyl)-5-methyl-;Doxribtimine;SS-THYMIDINE;β-Thymidine;Thymidine>99%;DThyd;dT

 

The development history of thymidine

 

 

The development history of thymidine epitomizes the evolution from biochemistry to pharmaceutical industry and finally to rare disease therapy:

 

1893: First isolated, ushering in the era of nucleic acid research;

1950–1960: Mechanisms elucidated, becoming a core tool in cell biology;

1987: Approval of Zidovudine(AZT) revolutionized the treatment history of HIV;

2025: Launch of KYGEVVI(doxecitine/doxribtimine) put an end to the "no treatment available" predicament for TK2d.

product-652-373

 

Specifications

 

Appearance

A white or almost white crystalline powder

Solution Clarity Test

Clear

Purity(HPLC)

≥98.00%

Assay(HPLC)

≥98.50%

Specific optical rotation

+17.5°~+19.5°

Water by K.F.

≤0.50%

Melting point

183℃~190℃

Residue ignition

≤0.30%

Related substances

2'-deoxyuridine ≤0.05%

Thymine ≤1.00%

Single impurity ≤0.10%

Total impurity ≤1.50%

 

Application

 

  • Used for anti-AIDS drugs (such as zidovudine, stavudine)

 

  • 2025-11-03: The FDA approved KYGEVVI (deoxycytidine + deoxythymidine) for the treatment of thymidine kinase 2 deficiency (TK2d). It is the world's first drug specifically for this ultra-rare mitochondrial myopathy, reducing the risk of death by 86%.

 

  • 2026-04-15: The European Commission granted simultaneous approval to KYGEVVI, indicated for children and adults with disease onset under 12 years of age, making it the first TK2d therapy authorized in the EU.

 

Production Process

 

We are equipped with mature production platforms of chemical synthesis and biological fermentation.With advanced process control, we ensure superior product purity, stable supply capacity and full compliance with pharmaceutical production requirements.

 

product-567-267

 

Other Information

 

Storage:Room temprature, tightly closed, protected from humidity.

Package:1kg/bag,5kg/drum, 25kg/drum

Drum packing: 2 plastic PE bags innerside + paper drum outside.

 

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